Hyperpolarised Magnetic Resonance Imaging Course

This course aims to provide advanced postgraduate level training in hyperpolarised magnetic resonance imaging (MRI), covering the full translational pathway from fundamental physics and polarisation methods through to preclinical and clinical applications. The course has been developed to address a recognised need for structured training in hyperpolarised MRI, a rapidly evolving field that requires integration of knowledge across physics, engineering, physiology, and clinical imaging. While the technology has advanced significantly in recent years, formal training opportunities remain limited and are often fragmented across disciplines.

The course has been designed within the framework of a multi-institutional research programme, drawing on expertise from leading international groups involved in the development and application of hyperpolarised MRI. The lecture series brings together specialists in polariser design, RF engineering, data acquisition, modelling, and organ-specific applications.

A key aim of the course is to provide participants with exposure to the full pipeline of hyperpolarised MRI development, from fundamental principles through to clinical application. By engaging with all stages of this process, participants gain an understanding of how different components interact, what constraints and assumptions arise at each stage, and how these influence both experimental design and interpretation. This broad perspective is intended to support the development of well-rounded researchers and practitioners, regardless of disciplinary background.

In addition to knowledge acquisition, the course is designed to develop critical evaluation and research skills through participant led projects, peer review, and structured reflection. By combining taught content with collaborative research activity, the course aims to foster a cohort of researchers and practitioners who are equipped to contribute to the ongoing development and translation of hyperpolarised MRI. The current delivery represents the first full implementation of the course, with a small cohort to allow refinement of content, structure, and assessment. Future iterations will build on this foundation and expand participation to a wider international audience as the field continues to grow.

The course comprises 19 weekly online sessions (~1 hour each) spread over 6 months, followed by an in person intensive week in Oxford (approximately 15–20 contact hours). Participants are also expected to undertake independent group project work (1-2 hours/week, increasing to ~3–5 hours/day during the in person week), giving a total study commitment of approximately 70-90 hours.

By the end of the course, participants will be able to:

• Explain the physical principles underlying hyperpolarisation techniques (e.g. DNP, PHIP) and their application in MRI.

• Describe the design and operation of key components including polarisers, RF coils, and acquisition strategies.

• Understand metabolic pathways relevant to hyperpolarised MRI and how these are probed in vivo.

• Describe the capabilities, limitations, and challenges of hyperpolarised MRI across preclinical and clinical applications.

• Interpret hyperpolarised MRI data, including metabolite ratios and dynamic measurements.

• Apply basic concepts of data reconstruction and modelling in hyperpolarised MRI.

• Critically evaluate experimental design, including factors affecting interpretation, repeatability, and reproducibility.

• Contribute to the design of research studies in hyperpolarised MRI.

• Work collaboratively to develop and present a research proposal.

• Critically assess scientific work and reflect on personal and team contributions.